Tramjet is a pain reliever which is used in the treatment of acute to moderate pain. It is highly safe and effective medicine which is used for the treatment of pain after surgery, cancer pain and to tender the muscles. It is also used as narcotic muscle relaxant drug.
Mechanism of action of Tramjet
Tramjet contains Tramadol as an active ingredient. Tramadol acts as m-opioid receptor agonist, serotonin reuptake inhibitor, norepinephrine reuptake inhibitor and as a releasing agent. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activates effector proteins. As the effector system is adenylate cyclase and cAMP is located at the inner surface of the plasma membrane, opioid decreases intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenalin is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord.
Dosage information for Tramjet
Tramjet is available in 50mg, 100mg, and 200mg extended release tablets. These tablets are to be taken orally with water before or after a meal. This medication is to be taken only after the prescription from the doctor. The maximum toxic dose of the drug is 600mg.
Missed Dose: In case the dose is missed, continue with the regular dose. However, if the between the skipped dose and regular dose is much, you can take the missed dose.
Overdose: In the case of overdose, seek medical attention as soon as possible.
There are some contraindications to be kept in mind while using Tramjet such as:
- Tramjet should not be taken during pregnancy and lactation
- Do not use Tramjet if you are hypersensitive to any of the ingredients of Tramjet
- Avoid using Tramjet if you are suffering from problem of chronic constipation
- Avoid using Tramjet if you are suffering from any kidney or liver damage issues
- Do not use Tramjet if you are taking any kind of medication linked to neurological disorder
- This medication is strictly inhibited in use with cardiac disorders
Tramjet is likely to cause drug interactions with Fluoxetine, Paroxetine, Amitriptyline, Quinidine, Digoxin, Ketoconazole, Carbamazepine, Cimetidine, Warfarin, Lithium and MAO inhibitors.
There are some possible side effects likely to occur with Tramjet such as headache, nausea, vomiting, drowsiness, allergic reactions, profused sweating and flushing, tachycardia, pain in stomach, anxiety and seizures.
Tramjet is to be stored at room temperature 250C to 300C; to be kept away from sunlight and moisture. Keep this medication out of reach from children and pets.
There are some precautions to be kept in mind while using Tramjet such as:
- Avoid driving or any other work that requires your alertness as this medication causes drowsiness effect
- Do not intake alcohol products as it may cause risk of serious adverse effects
- Not recommended for individuals less than 12 years of age