Angina - or angina pectoris is most commonly chest pain is a heart disorder that is associated with discomfort, or tightness that occurs when an area of the heart muscle is receiving reduced blood oxygen supply. It is a symptom of coronary artery disease, occurs when the artery becomes narrower resulting in lack of oxygen rich blood to the heart and that gradually make a plague like condition called atherosclerosis. The narrow arteries further increase the risk of pain, coronary artery disease, heart attack, and death. Angina typically lasts from 1 to 15 minutes. Angina can be classified into various forms, and are as follows-


Stable angina is a medical condition of heart when it is working harder than usual, such as during exercise and can be predicted in a longer period as months or in a year. Stable angina follows a regular pattern.


Chest pain in a long term if not treated properly may aggravate the condition and death associated with it is not uncommon, therefore a prompt, effective and suitable therapy should be undertaken to overcome the problem.


Unstable angina does not follow a regular pattern and occurs normally at rest and is more serious as it is not relieved by rest. Subsequent of unstable angina may lead to heart attacks within a short time or in a week.


Variant angina; other type of angina has been seen in person without any underlying coronary artery disease. It normally occurs with abnormal narrowing or spasm of the blood vessels and this may lead to reducing blood flow to the heart.


Most common causes of angina are less supply of oxygen rich blood to the heart possibly due to cholesterol aggregates on the artery wall and formation of hard plaques there and finally the artery narrows. Other causes includes such as smoking and high levels of fat or sugar in the blood and use of cocaine.


Chest pain in a long term if not treated properly may aggravate the condition and death associated with it is not uncommon, therefore a prompt, effective and suitable therapy should be undertaken to overcome the problem. Isordil Titradose is most commonly used and successfully proves to be the best approach to overcome angina. Presence of an active ingredient in the drug Isosorbide dinitrate, is manage chest pain by supplying more blood flow through the blood vessels, which reduces the workload of heart that needs to pump blood and thus chest pain get over.


How to use Isordil Titradose?


Oral formulation of Isordil Titradose should be taken by mouth on an empty stomach with a full glass of water. To get the better therapeutic response of this drug; start with minimum dose i.e. 5 mg to 20 mg; two or three times daily and gradually increase the dose up to 40mg. For maintenance therapy, 10 mg to 40 mg, two or three times daily is recommended. A dose interval of at least 14 hours is advisable to minimize tolerance.


What are the possible side effects of Isordil Titradose?


The side effects of the drug are basically due to the vasodilating effects of the blood like; flushing of the face and neck; headache; dizziness headache; light and swelling of the mouth, face, lips, or tongue.
These side effects are basically temporary in nature and can be vanished once the treatment is over. The safety margin of this Isordil Titradose as good as not every patient gets these side effects.


What is the important safety information about Isosorbide dinitrate?


Isordil Titradose has possibility to cause dizziness and it may worsen if you take it with alcohol or certain medicines and it is advised to the patient that to not perform driving or unsafe tasks during the course of therapy. To prevent the side effects of it; sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects. The drug may produce minor headache during the course of therapy; do not stop using this medication and discuss with healthcare providers to lessen this side effect. It should be used only with extreme caution in pregnant women or a nursing mother. If a patient is allergic to Isordil Titradose or any it's ingredient in it. Do not use this drug when you are facing from erectile dysfunction and taking drugs such as Sildenafil, Tadalafil, Vardenafil and Avanafil. Do not take any other drugs that affect cardiovascular drugs and cause lowering of blood pressure.


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