Lorazepam is one of the best-known medications indicated in the short-term management of severe anxiety. Lorazepam also has hypnotic, anticonvulsant, and considerable sedative effects and has been suggested as a pre-anesthetic agent. Lorazepam has a remarkable application in the management of sleeping trouble.
Mechanism of action of Lorazepam:
Lorazepam mainly binds to the allosteric site on GABA-A receptors, which are pentameric ionotropic receptors in the CNS. Binding of Lorazepam to GABA-A receptor potentiates the effects of the inhibitory neurotransmitter GABA, which after binding opens the chloride channel in the receptor, allowing chloride influx and causing hyperpolarization of the neuron. Thus, it reduces the over activity in the brain and produces calmness.
Dosage regimen of Lorazepam:
Lorazepam tablet should be taken orally with a glass full of water. If after taking the medicine, Lorazepam upsets your stomach, then take it with food or milk. You should take your medicine at regular intervals. Initially, a patient has to take 2 to 3mg of Lorazepam orally two to three times a day. After that, a person can take 1 to 2 mg of Lorazepam orally two to three times a day.
Contraindications of Lorazepam:
A patient should not use Lorazepam under these medical conditions:
- Narrow-angle glaucoma;
- Myasthenia gravis
- Hypersensitive reactions with Lorazepam
Precautions while taking Lorazepam:
- You should talk to your doctor if you have kidney or liver disease, bipolar disorder, depression, glaucoma, lung disease, Parkinson's disease before taking Lorazepam.
- If you are pregnant or a lactating mother, then consult your doctor before taking Lorazepam.
- Do not drink alcohol while you are taking Lorazepam.
- Do not operate dangerous machinery or motor vehicles while using this medication.
- You should not use Lorazepam for more than four weeks.
- Do not stop taking Lorazepam all of a sudden because you may experience withdrawal symptoms.
Side effects of Lorazepam:
Some common side effects include constipation, diarrhea, difficulty in sleeping, nightmares, dizziness, drowsiness, headache, nausea, vomiting and weakness or tiredness.
Lorazepam increases CNS-depressant effects when administered with other CNS depressants such as barbiturates, antipsychotics, sedative/hypnotics, anxiolytics, antidepressants, narcotic analgesics, antihistamines, anticonvulsants, and anesthetics.